Choosing the proper effect filters and determining the require filtration area can be accomplished using laboratory filtration trials. First decide on the appropriate level of clarity, and then choose a grade of filter medium that should provide this clarity, as based upon either particle distribution data or manufacturers recommendation. A number of filter grades might be evaluated before a selection is made. A minimum amount of the preparation being readied for processing is dedicated to trial testing stop properly perform, such evaluating test can provide the data necessary to ensure the correct size filtration system for full scale production. Determine how much effective filtration area is required to perform the testing. The smaller the effective filtration area the less product need be expanded to complete the testing. If the area of filter medium is too small, surface tension effects may result. A 47mm diameter filter this is a common trial size for flat filter media. In a 47mm diameter housing every milliliter of product filter can equate with 0.8 L/m2 of throughput in the production mode using appropriately larger filter.
The selection by trial can next be meat of the filter medium in terms of porosity. The choice of a membrane filter of the correct pore size rating can be determined by testing several different possibilities. If necessary, compatibility can be assayed using membranes of different polymeric compositions
The same approach can be taken for the optimization of preexisting filtration processes. If the current processes have not been addressed in many years, and are still operating under the original conditions, parameters may have change. A new experimental investigation may disclose potential improvements. The filtration area can be reduced, filtration costs save or faster batch times yielded The trials can be performed at the end user sites, at the suppliers local technical service facilities or at the filter medium manufacturers laboratories.